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“Our objective is to be familiar with female reproductive aging, and why fertility fast declines starting off during the mid-30s,” suggests Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata performs.
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Munakata and Namekawa will compare mice with normal and mutated variations from the chromatin remodeler. As being the mice develop and experienced, they can observe whether or not the presence or absence of this protein triggers variations within the arrangement of DNA spools within the animals’ oocytes. And they will check no matter whether this, in turn, alters the pattern of gene expression over time.
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This protein might “establish and preserve the chromatin state,” says Namekawa — maintaining the spools in place and the oocytes genetically primed as the mouse matures.
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